Pediatric TBI Study


The goal of this research project is to learn more about traumatic brain injuries in pediatric patients. We hope to gain a better understanding of brain injuries and their resultant symptoms in an understudied population.


Research participants from the Emergency Department at Dell Children's Medical Center provide blood and saliva samples for analysis. Our team examines biomarkers in participants' samples that can be used for diagnosis and prognosis of traumatic brain injury.   

By understanding the biological changes that occur after brain injury, this information can facilitate healthcare providers in utilizing precision care efforts. 


Research Participants

To our research participants, thank you for not only your contributions to our study but also for advancing knowledge. 


Research Participant Timeline

Baseline: Enrollment

  • Blood Draw 

  • Baseline Surveys (PROMIS and Neuro-QoL)

  • $25 Compensation upon completion

Three Months after Enrollment

  • 3-Month Surveys (same as baseline)

  • $25 Compensation upon completion

Six Months after Enrollment

  • 6-Month Surveys (same as baseline)

    • $25 compensation upon completion​

  • Saliva Sample

    • $25 compensation upon return​


You may contact the Principal Investigator, Dr. Osier 


This study has been reviewed and approved by The University Institutional Review Board. The study number is 2018-04-0018. 

For questions about your rights or any dissatisfaction with any part of this study, you can contact, anonymously if you wish, the Institutional Review Board 



Research Methods

Using various techniques such as ELISA, the Osier group is focused on gathering data based primarily on inflammatory markers within the body, such as interleukin-10, interleukin-6 and amyloid-beta 42, among others.


We hope to quantitatively measure the differences in protein expression presented in our study participants based on the initial injury, the duration since the injury, and severity of acute and chronic symptoms, both physical and psychological, and how that relates to the background genetic nature of the individual, compared to his or her paired control. So far, we have analyzed over 180 samples, with many more on the way.